JSCS Vol 64, No. 1
J. Serb. Chem. Soc. 64(1) 1-7 (1999)
UDC 547.587.51:615.281
JSCS-2616
Original scientific paper
A novel synthesis of heterocyclic
compounds containing coumarin moiety of potential antimicrobial activity
M. E. ABD EL-FATTAH
Chemistry Department, Faculty of
Science, Suez Canal University, Ismaillia, Egypt
(Received 8 July 1998)
The chemical reaction of 4-methyl-2-oxo-2H-benzopyran-7-yloxyacetic
acid hydrazide (2) with some different reagents, such as anhydride
compounds, aromatic aldehydes, carbon disulphide, and nitrous acid, yielded the
corresponding phthalazine derivatives 3, 4, 5, hydrazone derivatives 6a-c,
1,3,4-oxadiazol derivative 8 and acid azide 10, respectively.
Treatment of 10 with absolute alcohols, amines and ethyl amino acid
esters gave the corresponding carbamate derivatives 11a,b, substituted
urea derivatives 12a,b, and substituted ethyl acetate 13a-c, respectively.
The biological activities of some of the synthesized compounds were evaluated.
Key
words: heterocycles, coumarin, synthesis, antimicrobiol activity.
J. Serb. Chem. Soc. 64(1) 9-18 (1999)
UDC 547.772.2/.779
JSCS-2617
Original scientific paper
Synthesis and biological activity
of some pyrazole derivatives
EL-SAYED H. EL-TAMANY, FAKHER A. EL-SHAHED and BELAL H. MOHAMED
Chemistry Department, Faculty of
Science, Suez Canal University, Ismailia, Egypt
(Received 17 July 1998)
The
4-arylidene-3-methyl-1-phenyl-2-pyrazolinones 1a-c react with some
active methylene compounds, under Michael reaction conditions, to give the
pyrano[2,3-c] pyrazole derivatives 2-6. Reactions of 2a-c with some
compounds were carried out. Ring-chain tautomerism with cleavage was observed
in their reactions with some species. All the newly synthesized compounds were
tested against some bacteria and some of the compounds were found to be biologically
active.
Key
words: pyrazoles, biological activity, ring-chain tautomerism.
J. Serb. Chem. Soc. 64(1) 21-30 (1999)
UDC 547.962:66.066.067:615.37
JSCS-2618
Original scientific paper
Isolation, purification and
characterization of the flagellin Campylobacter jejuni PEN 19
DONKA LANGE-KOVACEVIC, STOJANKA ALEKSIC*, MIROSLAV M.
VRVIC** and IVANKA KARADZIC***
Johnson & Johnson Medical,
Ostrasse 1, 22844 Norderstedt, Germany,
*National Referent Zentrum fur Enteritis Erreger und Yersiniosen,
Hygienisches Institut,
Marckmannstr. 129a, 20539 Hamburg, Germany,
**Faculty of Chemistry, University of Belgrade, Studentski trg 16,
P.O.Box 158, 11001 Belgrade, Yugoslavia and
***School of Medicine, Institute of Chemistry, University of
Belgrade, Visegradska 26, 11000 Belgrade, Yugoslavia
(Received 29 July,
revised 5 November 1998)
Two different methods were used for the
isolation and purification of the flagellin Campylobacter jejuni,
serotype O19 (PEN 19). In the first method, the flagellin proteins were
isolated and purified to homogeneity by mechanical shearing and differential
ultracentrifugation. In the another method applied, the flagellin was isolated
and purified by acid dissociation, differential ultracentrifugation, neutral pH
reassociation and ammonium sulfate precipitation of the protein. The flagellin
preparations were of a high degree of purity as demonstrated by transmission
electron microscopy and SDS-PAGE. One single band with molecular mass 68 kD was
obtained. Immunization of rabbits with the flagellin preparations produced
antiserum with high H agglutination titters. Immunodiffusion and
immunoelectrophoresis of the flagellin preparations exhibited single
precipitation band indicating homogeneity.
Key
words: Campylobacter jejuni, flagellin, TEM, SDS-PAGE,
immunoelectrophoresis.
J.
Serb. Chem. Soc. 64(1) 31-37 (1999)
UDC 547.415.1:546.73-541.426.49
JSCS-2619
Original scientific
paper
Synthesis and characterization of uns-cis-(1,3-propane-diamine-N,N'-diacetato)cobalt(III)
complexes with symmetrical b-diketonato ligands
SRECKO R. TRIFUNOVIC, NELA VUCKOVIC, SLOBODAN A. GRUJIC, ZIVOSLAV
LJ. TESIC* and
TIBOR J. SABO*
Faculty of Science, Department of
Chemistry, University of Kragujevac, P.O.Box 60, YU-34000 Kragujevac,
*Faculty of Chemistry, University of Belgrade, P.O.Box 158,
YU-11001 Belgrade, Yugoslavia
(Received 26 August
1998)
The mixed uns-cis(b-diketonato)(1,3-propanediamine-N,N'-diacetato)cobalt(III)
complexes (b-diketonato ligands = 2,4-pentanedione,
1,3-diphenyl-1,3-propanedione and 2,2,6,6-tetramethyl-3,5-heptanedione) were
prepared by the reaction of sodium uns-cis-(1,3-propanediamine-N,N'-diacetato)(carbonato)cobaltate(III)
and the corresponding symmetrical b-diketone at 75 °C. The complexes were
isolated chromatographically and characterized by elemental analysis, infrared
and electron absorption spectroscopy.
Key
words: synthesis, cobalt(III) complexes, 1,3-propanediamine-N,N'-diacetic
acid, b-diketonates.
J.
Serb. Chem. Soc. 64(1) 39-45 (1999)
UDC 547.461/.2:661.8.465
JSCS-2620
Original scientific
paper
Reaction between oxalic acid and Na2HAsO4. A
conductometric and pH metric investigation
M. V. OBRADOVIC, S. S. MITIC, S. M. SUNARIC and D. S. VESELINOVIC*
Department of Chemistry, Faculty of
Philosophy, University of Nis, YU-18000 Nis, and
*Faculty of Physical Chemistry, University of Belgrade, P.O.Box
137, YU-11001 Belgrade, Yugoslavia
(Received 10 July,
revised 21 October 1998)
The reaction between Na2HAsO4 and oxalic acid was studied by pH-metric and
conductometric measurements, applying the methods of continual variations. It
was found that the oxalic acid forms a complex of the type [HAsO3C2O4]2- .The stability constants and thermodynamic parameters for the
complex reaction were calculated using the data obtained by pH-metric
measurements at 25±1 °C.
Key
words: arsen(V), oxalic acid, complex, conductometry, pH-metry.
J. Serb. Chem .Soc. 64(1) 47-53 (1998)
UDC 541.138/.183.5:546.57/548.21/
JSCS-2621
Preliminary communication
PRELIMINARY COMMUNICATION
Electrosorption
of bromide ions onto silver single crystals
B. M. JOVIC,1 D. M. DRAZIC* and V. D. JOVIC**
nstitute of Technical Science of
the Serbian Academy of Sciences and Arts, YU-11001 P.O.Box 745, Belgrade,
*Institute of Electrochemistry ICTM, YU-11000, Njegoseva 12,
Belgrade and
**Center for Multidisciplinary Studies, University of Belgrade,
P.O. Box 33, YU-11030 Belgrade, Yugoslavia
(Received
22 September 1998)
Electrosorption
of bromide ions onto the (111), (100) and (110) silver single crystal faces
from solutions of different concentration was investigated by cyclic
voltammetry. It was shown that the shape of the voltammograms depends
significantly on the single crystal orientation and that in all cases a
monolayer of AgBr of the corresponding orientation was formed as the final
product of electrosorption process. By deconvolution of the CV peaks obtained
on the (111) face and by their fitting with the Frumkin adsorption isotherm, it
was shown that the electrosorption process takes place throught four different
stages of the adsorbate, two of them (appearing at more negative potentials)
being characterized by repulsive forces and the other two by attractive forces
between the adsorbed species. By the analysis of the Ea,p - log n
dependences, it was shown that, as in the case of chloride ions
electrosorption, the mechanism of bromide electrosorption is complex, taking
place through three or four steps, with the rate determining one being either
the chemical reaction of AgBr formation, or the 2D crystallization of the AgBr
layer.
Key
words: electrosorption of Br-, silver single crystals, Frumkin
adsorption isotherm, 2D crystallization of AgBr.
J.
Serb. Chem. Soc. 64(1) 55-60 (1999)
UDC 661.887:543.063/064
JSCS-2622
Original scientific paper
Kinetic determination of ultra
micro amounts of Bi(III)
TODOR G. PECEV, RANGEL P. IGOV, VESNA P. STANKOV-JOVANOVIC and
VIOLETA D. MITIC
Faculty of Philosophy, University
of Nis, YU-18000 Nis, Yugoslavia
(Received
1 July, revised 9 October 1998)
The
new indicator reaction is suggested and a new kinetic method developed for
Bi(III) traces determination. We observed that Bi(III) ions have a catalytic
influence on the hematoxylin (HT) oxidation process by hydrogen peroxide in
perchloric acid solution. The sensitivity of the method is 0.08 µg cm-3. The
probable relative error is 2.3-10.5% for Bi(III) concentrations in the interval
0.08
µg cm -3 to 0.23 µg cm-3. Kinetic equations for the
uncatalysed and the catalytic processes were derived. The selectivity of the
method is good. The method was applied for Bi(III) determination in aluminum
containing traces of Ag. The obtained results are comparable with those
obtained by the AAS hydride method.
Key
words: kinetic determination, bismuth(III), hematoxylin.
J.
Serb. Chem. Soc. 64(1) 61-69 (1999)
UDC 546.571:543.063/.064
JSCS-2623
Original scientific paper
Catalytic titrations of silver(I)
applying the iodide-catalysed manganese(IV)-arsenic(III) indicator reaction in
the presence of sulphuric acid
TIBOR J. PASTOR, VOJKA V. ANTONIJEVIC and FERENC T. PASTOR
Faculty of Chemistry, University of
Belgrade, Akademski trg 12-16, P.O.Box 158, YU-11001 Belgrade, Yugoslavia
(Received
9 October 1998)
A
new catalytic potentiometric titration method for the determination of
silver(I), applying the iodide-catalysed manganese(IV)-arsenic(III) indicator
reaction in the presence of sulphuric acid, has been developed. The effect of
the concentration of sulphuric acid and different ions, and of the mole ratio
of manganese(IV) to arsenic(III) in the titrated solution, as well as of the
titrand temperature on the conditions for the determination of silver(I) in
solutions of various concentrations, was investigated. The error in the
determination of 0.5 µg cm-3 silver(I) was less than 2%, with
good reproducibility. Small quantities of 2-PAM iodide, as well as silver in a
silver-zinc alloy were determined by the developed method.
Key
words: catalytic potentiometric titration, silver(I), iodide, Mn(IV)-As(III)
indicator reaction, sulphuric acid.
J. Serb. Chem. Soc.64(1) 71-82 (1999)
UDC 547.565.2:543.274
JSCS-2624
Technical paper
Expert system for catalytic
titrimetry. Part. 3. Determination of monobasic non-carboxylic acids.
BILJANA F. ABRAMOVIC, BORISLAV K. ABRAMOVIC*, FERENC F. GAÁL and
DANILO M. OBRADOVIC*
Institute of Chemistry, Faculty of
Science, University of Novi Sad, Trg D. Obradovica 3, YU-21000 Novi Sad, and
*Computer, Control and Measurement Institute, Faculty of Technical
Sciences, University of Novi Sad, Fruskogorska 11, YU-21000 Novi Sad,
Yugoslavia
(Received 28 August
1998)
A part of the expert system (ES) to solve the
problem of choosing a catalytic titrimetric procedure for the determination of
monobasic non-carboxylic acids is described. The presented segment of the ES,
on the basis of the behaviour of non-carboxylic acids in catalytic titrations
using either different indicator reactions, or titrant and/or solvent on the
one hand, and the possibility of their selective determination on the other, is
divided into five modules. Each module encompasses a defined group of
compounds, namely: phenols and naphthols, thiols, sulphonamides, keto-enols and
imides, and thioamides and other.
Key
words: expert system, catalytic titrations, monobasic non-carboxylic acids,
selective determination.
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